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Purified Anti-Human HLA-DR Antibody [L243] (AGEL0413)

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SKU AGEL0413
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human
Host Species Mouse
Isotype IgG2a
Clone L243
Conjugation Unconjugated
Applications FC
Applications WB
Applications IHC
Applications IP
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Description

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Purified Anti-Human HLA-DR Antibody [L243]

The Human HLA-DR Monoclonal Antibody L243 (AGEL0413) is a powerful tool for research in immunology and histocompatibility. This monoclonal antibody specifically targets the HLA-DR protein, a key molecule in the human major histocompatibility complex (MHC) responsible for presenting antigens to T-helper cells. The L243 antibody is highly specific for human samples, enabling precise detection and analysis in various experimental settings.HLA-DR is essential for the immune system to distinguish between self and non-self antigens, playing a crucial role in adaptive immunity and immune response regulation. The L243 monoclonal antibody allows for the identification and characterization of HLA-DR expression in different cell types and tissues, facilitating studies on immune system function, transplantation, infectious diseases, and autoimmune disorders.

By using the HLA-DR Monoclonal Antibody L243 (AGEL0413), researchers can delve deeper into the mechanisms of antigen presentation, immune recognition, and immune tolerance. This antibody is a valuable tool for investigating the complexities of the human immune system and its involvement in various health conditions, providing insights that can contribute to the development of novel therapeutic approaches and personalized medicine strategies.

Product Title:Purified Anti-Human HLA-DR Antibody [L243]
SKU:AGEL0413
Size:25µg, 100µg
Clone No:L243
Synonyms:HLA class II histocompatibility antigen DR alpha/ DRB1-15 beta chain;MHC class II antigen DRA;HLA-DRA1/DRB1;DRA/DRB1;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Purified Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P01903 P01911
Gene ID:3122,3123
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kD α (heavy) chain and a 27 kD β (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells.

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