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Hmgcs1 Antibody (PACO37762)

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SKU PACO37762
Product Type Antibody
Reactivity Mouse
Host Species Rabbit
Isotype IgG
Applications ELISA
Antibody Type Polyclonal Antibody
Conjugation Unconjugated
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Description

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Hmgcs1 Antibody (PACO37762)

The HMGCS1 Polyclonal Antibody (PAC037762) is a valuable tool for researchers studying the HMGCS1 protein, an enzyme involved in the regulation of ketogenesis and cholesterol synthesis. This antibody, raised in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the HMGCS1 protein, this antibody enables the detection and analysis of HMGCS1 in various cell types, making it ideal for studies in metabolic disorders, lipid metabolism, and related diseases.

HMGCS1, also known as 3-hydroxy-3-methylglutaryl-CoA synthase 1, plays a crucial role in ketone body production and cholesterol synthesis, making it an important target for research into metabolic disorders such as diabetes, obesity, and cardiovascular diseases. Understanding the function of HMGCS1 is essential for developing therapeutic strategies aimed at modulating ketogenesis and lipid metabolism to treat these conditions effectively.

Antibody Name:Hmgcs1 Antibody (PACO37762)
Antibody SKU:PACO37762
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse Hydroxymethylglutaryl-CoA synthase, cytoplasmic protein (1-520AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Synonyms:Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase), Hmgcs1
UniProt Protein Function:HMGCS1: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the HMG-CoA synthase family.Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC 2.3.3.10; Lipid Metabolism - synthesis and degradation of ketone bodies; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; TransferaseChromosomal Location of Human Ortholog: 13 D2.3|13Cellular Component: cytoplasm; cytosolMolecular Function: catalytic activity; drug binding; hydroxymethylglutaryl-CoA synthase activity; isomerase activity; organic acid binding; protein homodimerization activity; transferase activityBiological Process: cholesterol biosynthetic process; cholesterol metabolic process; isoprenoid biosynthetic process; lipid metabolic process; metabolic process; response to low density lipoprotein stimulus; response to purine; steroid biosynthetic process; steroid metabolic process; sterol biosynthetic process
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q8JZK9
NCBI GenInfo Identifier:612339316
NCBI Gene ID:208715
NCBI Accession:NP_001278368.1
UniProt Secondary Accession:Q8JZK9,Q3UXI4
UniProt Related Accession:Q8JZK9
Molecular Weight:
NCBI Full Name:hydroxymethylglutaryl-CoA synthase, cytoplasmic
NCBI Synonym Full Names:3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
NCBI Official Symbol:Hmgcs1  
NCBI Official Synonym Symbols:B130032C06Rik  
NCBI Protein Information:hydroxymethylglutaryl-CoA synthase, cytoplasmic
UniProt Protein Name:Hydroxymethylglutaryl-CoA synthase, cytoplasmic
UniProt Synonym Protein Names:3-hydroxy-3-methylglutaryl coenzyme A synthase
Protein Family:
UniProt Gene Name:Hmgcs1  
UniProt Entry Name:

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