Description
HMGN5 Antibody (PACO16794)
The HMGN5 Polyclonal Antibody (PACO16794) is an essential tool for researchers studying HMGN5, a protein known for its involvement in chromatin remodeling and gene regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting HMGN5 in human samples, making it a reliable choice for Western blot applications. By targeting HMGN5, researchers can gain valuable insights into its function and role in various cellular processes.HMGN5, a member of the high mobility group nucleosome binding protein family, is important for modulating chromatin structure and gene expression. Its dysregulation has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting the significance of studying its function.
The HMGN5 Polyclonal Antibody allows for precise detection of HMGN5 in different cell types, enabling researchers to explore its implications in disease development and progression.Investigating HMGN5 with the help of this antibody can pave the way for the development of targeted therapies and interventions aimed at addressing disorders associated with HMGN5 dysregulation. Its utility in research related to gene regulation and chromatin dynamics makes it a valuable tool for advancing our understanding of HMGN5 biology and its implications in disease pathology.
| Antibody Name: | HMGN5 Antibody (PACO16794) |
| Antibody SKU: | PACO16794 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human HMGN5 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO16794(HMGN5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: PACO16794(HMGN5 Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16794(HMGN5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. |
| Synonyms: | high mobility group nucleosome binding domain 5 |
| UniProt Protein Function: | NSBP1: Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. Belongs to the HMGN family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: Xq13.3 Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus Molecular Function:chromatin binding Biological Process: negative regulation of apoptosis; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P82970 |
| NCBI GenInfo Identifier: | 23396771 |
| NCBI Gene ID: | 79366 |
| NCBI Accession: | P82970.1 |
| UniProt Secondary Accession: | P82970,Q5JSL1, |
| UniProt Related Accession: | P82970 |
| Molecular Weight: | 31,525 Da |
| NCBI Full Name: | High mobility group nucleosome-binding domain-containing protein 5 |
| NCBI Synonym Full Names: | high mobility group nucleosome binding domain 5 |
| NCBI Official Symbol: | HMGN5Â Â |
| NCBI Official Synonym Symbols: | NSBP1; NBP-45Â Â |
| NCBI Protein Information: | high mobility group nucleosome-binding domain-containing protein 5 |
| UniProt Protein Name: | High mobility group nucleosome-binding domain-containing protein 5 |
| UniProt Synonym Protein Names: | Nucleosome-binding protein 1 |
| Protein Family: | High mobility group nucleosome-binding domain-containing protein |
| UniProt Gene Name: | HMGN5Â Â |
| UniProt Entry Name: | HMGN5_HUMAN |
