Description
HMGN5 Antibody (PACO18783)
The HMGN5 Polyclonal Antibody (PAC018783) is a valuable tool for researchers studying HMGN5, a protein involved in chromatin organization and gene expression regulation. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blot and immunofluorescence.HMGN5 is a member of the high-mobility group nucleosome-binding protein family, known for its role in modulating chromatin structure and influencing gene transcription.
Its function in regulating gene expression makes it a target of interest in the fields of epigenetics and cancer research.By using the HMGN5 Polyclonal Antibody, researchers can detect and analyze HMGN5 protein levels in cell samples, allowing for a better understanding of its molecular mechanisms and potential implications in disease development. This antibody is a valuable tool for studies aiming to uncover the role of HMGN5 in various cellular processes and disease pathways.
| Antibody Name: | HMGN5 Antibody (PACO18783) |
| Antibody SKU: | PACO18783 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human HMGN5 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18783(HMGN5 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. |
| Synonyms: | High mobility group nucleosome binding domain 5 |
| UniProt Protein Function: | NSBP1: Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. Belongs to the HMGN family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: Xq13.3 Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus Molecular Function:chromatin binding Biological Process: negative regulation of apoptosis; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P82970 |
| NCBI GenInfo Identifier: | 23396771 |
| NCBI Gene ID: | 79366 |
| NCBI Accession: | P82970.1 |
| UniProt Secondary Accession: | P82970,Q5JSL1, |
| UniProt Related Accession: | P82970 |
| Molecular Weight: | 31,525 Da |
| NCBI Full Name: | High mobility group nucleosome-binding domain-containing protein 5 |
| NCBI Synonym Full Names: | high mobility group nucleosome binding domain 5 |
| NCBI Official Symbol: | HMGN5Â Â |
| NCBI Official Synonym Symbols: | NSBP1; NBP-45Â Â |
| NCBI Protein Information: | high mobility group nucleosome-binding domain-containing protein 5 |
| UniProt Protein Name: | High mobility group nucleosome-binding domain-containing protein 5 |
| UniProt Synonym Protein Names: | Nucleosome-binding protein 1 |
| Protein Family: | High mobility group nucleosome-binding domain-containing protein |
| UniProt Gene Name: | HMGN5Â Â |
| UniProt Entry Name: | HMGN5_HUMAN |
