The HNF1 Monoclonal Antibody is a specialized tool for researchers studying the hepatocyte nuclear factor 1 (HNF1) protein, a key transcription factor involved in liver development and function. This antibody, produced using hybridoma technology, exhibits high specificity and sensitivity for detecting HNF1 in human samples, making it a valuable asset for Western blot and immunohistochemistry applications.HNF1 is known to regulate the expression of genes involved in glucose metabolism, lipid synthesis, and bile acid production, making it a crucial player in metabolic processes and liver physiology.
Dysregulation of HNF1 has been linked to various liver diseases, including hepatocellular carcinoma and diabetes.By using the HNF1 Monoclonal Antibody, researchers can gain insight into the role of HNF1 in liver biology and disease pathology, ultimately paving the way for the development of targeted therapies for liver-related disorders. This antibody is a reliable tool for advancing research in hepatology, molecular biology, and personalized medicine.
Product Name:
HNF1α Monoclonal Antibody
SKU:
CAB22139
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 31-128 of human HNF1α (NP_000536.6).
Sequence:
GEPG PYLL AGEG PLDK GESC GGGR GELA ELPN GLGE TRGS EDET DDDG EDFT PPIL KELE NLSP EEAA HQKA VVET LLQE DPWR VAKM VKSY LQQH NI
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
6927
Clone Number:
ARC55848
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Mouse kidney using HNF1α Rabbit mAb (CAB22139) at dilution of 1:100(40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
