Description
HORMAD1 Antibody (PACO00928)
The Hormad1 Polyclonal Antibody (PACO00928) is an essential tool for researchers studying Hormad1, a key protein involved in meiotic recombination and gametogenesis. This polyclonal antibody, generated in rabbits, is highly specific and reacts strongly with human samples, making it a reliable choice for various research applications.Hormad1 is a crucial player in the process of meiosis, contributing to the formation of genetic diversity and proper chromosome segregation during gamete formation. Dysregulation of Hormad1 has been linked to infertility and genetic disorders, highlighting its importance in reproductive biology research.By using the Hormad1 Polyclonal Antibody, researchers can accurately detect and analyze Hormad1 expression in different cell types and tissues, providing valuable insights into its function and dysregulation in various diseases.
This antibody is validated for use in techniques such as Western blotting, immunofluorescence, and immunohistochemistry, making it a versatile tool for studying Hormad1 biology.Overall, the Hormad1 Polyclonal Antibody is an invaluable resource for scientists investigating meiosis, reproductive biology, and genetic disorders, offering reliable and specific detection of Hormad1 protein in their experimental systems.
| Antibody Name: | HORMAD1 Antibody |
| Antibody SKU: | PACO00928 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the C-terminal region of human HORMAD1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | HORMAD1; NOHMA; HORMA domain-containing protein 1; Cancer/testis antigen 46; CT46; Newborn ovary HORMA protein |
| UniProt Protein Function: | HORMAD1: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cancer Testis Antigen (CTA) Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: chromosome; nucleus Biological Process: blastocyst development; meiosis; meiotic DNA double-strand break formation; meiotic recombination checkpoint; meiotic sister chromatid cohesion; oogenesis; spermatogenesis; synaptonemal complex assembly |
| NCBI Summary: | This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q86X24 |
| NCBI GenInfo Identifier: | 74750516 |
| NCBI Gene ID: | 84072 |
| NCBI Accession: | Q86X24.1 |
| UniProt Secondary Accession: | Q86X24,Q4G114, Q5T5I3, Q5T5I4, Q5T5I5, Q6FIC1, Q9H0K8 A6NMK2, B3KUK1, |
| UniProt Related Accession: | Q86X24 |
| Molecular Weight: | 36,676 Da |
| NCBI Full Name: | HORMA domain-containing protein 1 |
| NCBI Synonym Full Names: | HORMA domain containing 1 |
| NCBI Official Symbol: | HORMAD1Â Â |
| NCBI Official Synonym Symbols: | CT46; NOHMAÂ Â |
| NCBI Protein Information: | HORMA domain-containing protein 1 |
| UniProt Protein Name: | HORMA domain-containing protein 1 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 46; CT46; Newborn ovary HORMA protein |
| Protein Family: | HORMA domain-containing protein |
| UniProt Gene Name: | HORMAD1Â Â |
| UniProt Entry Name: | HORM1_HUMAN |
