The HOXA4 Polyclonal Antibody (PAC018078) is a valuable tool for researchers studying the HOXA4 protein, a critical regulator of gene expression in development and disease. This antibody, produced in rabbits, exhibits high specificity for human samples and is optimized for use in Western blot experiments. By binding to HOXA4, this antibody allows for precise detection and analysis of the protein in various cell types, making it an essential component of studies in developmental biology and cancer research.
HOXA4 is a member of the HOX gene family, which plays a fundamental role in determining cell fate and differentiation during embryonic development. Dysregulation of HOXA4 expression has been linked to various diseases, including cancer and developmental disorders. Investigating the function of HOXA4 is essential for understanding its impact on gene regulation and cellular processes, with potential implications for therapeutic interventions in related conditions.
Antibody Name:
HOXA4 Antibody (PACO18078)
Antibody SKU:
PACO18078
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human HOXA4
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18078(HOXA4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18078(HOXA4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation
Synonyms:
homeobox A4
UniProt Protein Function:
HOXA4: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT- 3'. Belongs to the Antp homeobox family. Deformed subfamily.Protein type: DNA-binding; Transcription factorChromosomal Location of Human Ortholog: 7p15.2Cellular Component: nucleusMolecular Function: sequence-specific DNA binding; transcription factor activityBiological Process: anterior/posterior pattern formation; anatomical structure morphogenesis; regulation of transcription, DNA-dependent; transcription, DNA-dependent; embryonic skeletal morphogenesis
UniProt Protein Details:
NCBI Summary:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]
