The HRASLS2 Polyclonal Antibody (PAC019781) is a valuable tool for researchers studying HRASLS2, a protein involved in lipid metabolism and cell signaling processes. This antibody, produced in rabbits, is highly specific and exhibits strong reactivity with human samples. Validated for use in Western blot applications, it binds to the HRASLS2 protein, allowing for accurate detection and analysis in a variety of cell types.HRASLS2, also known as PLSCR3, plays a key role in mediating cell growth, differentiation, and apoptosis through its interactions with lipid molecules.
Its involvement in lipid metabolism pathways makes it a promising target for research in areas such as metabolic disorders, cancer, and cardiovascular diseases. Understanding the function and regulation of HRASLS2 is essential for uncovering its potential as a therapeutic target in various disease contexts.Overall, the HRASLS2 Polyclonal Antibody is a reliable tool for investigating the role of HRASLS2 in cellular processes and disease mechanisms, providing valuable insights for the development of novel therapeutic strategies.
Antibody Name:
HRASLS2 Antibody (PACO19781)
Antibody SKU:
PACO19781
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human HRASLS2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19781(HRASLS2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19781(HRASLS2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
HRASLS2 (HRAS-like suppressor 2), also known as PLA1/2-2, is a 162 amino acid, cytoplasmic protein that belongs to the H-rev107 family. Expressed in liver, kidney, small intestine and colon, HRASLS2 exhibits PLA1/2 activity by catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PCs) and phosphatidylethanolamine (PE).
Synonyms:
HRAS-like suppressor 2
UniProt Protein Function:
H1R: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-passChromosomal Location of Human Ortholog: 3p25Cellular Component: nucleoplasm; integral to plasma membrane; cytoplasm; plasma membraneMolecular Function: G-protein coupled receptor activity; histamine receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; inositol phosphate-mediated signaling; positive regulation of vasoconstriction; eosinophil chemotaxis; regulation of synaptic plasticity; visual learning; positive regulation of inositol trisphosphate biosynthetic process; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of vascular permeability; inflammatory response; memory
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016]
