The HRASLS2 Polyclonal Antibody (PACO19782) is a valuable tool for researchers studying HRASLS2, a protein involved in lipid metabolism and cellular signaling pathways. The antibody, produced in rabbits, is highly specific to human samples and is suitable for use in various applications, including Western blotting. By targeting the HRASLS2 protein, this antibody allows for the detection and analysis of HRASLS2 expression in different cell types, making it ideal for research in lipid biology and cancer studies.HRASLS2, also known as HRAS-like suppressor 2, plays a crucial role in regulating lipid metabolism and cell growth, making it a potential target for therapeutic interventions in metabolic disorders and cancer.
Understanding the function of HRASLS2 can provide insights into the mechanisms underlying these conditions and aid in the development of novel treatment strategies. By using the HRASLS2 Polyclonal Antibody, researchers can further explore the role of HRASLS2 in health and disease, advancing our understanding of lipid metabolism and cellular signaling pathways.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19782(HRASLS2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse kidney tissue, Mouse liver tissue, human fetal liver tissue, Primary antibody: PACO19782(HRASLS2 Antibody) at dilution 1/362.5, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19782(HRASLS2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
HRASLS2 (HRAS-like suppressor 2), also known as PLA1/2-2, is a 162 amino acid, Cytoplasmic protein that belongs to the H-rev107 family. Expressed in liver, kidney, small intestine and colon, HRASLS2 exhibits PLA1/2 activity by catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PCs) and phosphatidylethanolamine (PE).
Synonyms:
HRAS-like suppressor 2
UniProt Protein Function:
H1R: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-passChromosomal Location of Human Ortholog: 3p25Cellular Component: nucleoplasm; integral to plasma membrane; cytoplasm; plasma membraneMolecular Function: G-protein coupled receptor activity; histamine receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; inositol phosphate-mediated signaling; positive regulation of vasoconstriction; eosinophil chemotaxis; regulation of synaptic plasticity; visual learning; positive regulation of inositol trisphosphate biosynthetic process; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of vascular permeability; inflammatory response; memory
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016]
