The HSD17B11 Polyclonal Antibody (PACO09807) is a valuable tool for researchers studying the HSD17B11 protein, an enzyme involved in steroid metabolism. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples and is validated for use in various applications, including Western blotting.HSD17B11 plays a crucial role in the biosynthesis and metabolism of steroid hormones, making it of interest in studies related to endocrinology, reproductive biology, and hormone-related disorders. By targeting the HSD17B11 protein, researchers can gain insights into its function and regulation in different cell types, providing valuable information for drug development and therapeutic interventions in hormone-related conditions.
With its versatile applications and specificity towards the HSD17B11 protein, the PACO09807 antibody is an essential tool for researchers seeking to unravel the complexities of steroid metabolism and hormone signaling pathways. Its use can potentially lead to advancements in the understanding and treatment of various hormone-related disorders and conditions.
HSD17B11: Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.Protein type: Secreted, signal peptide; Secreted; Oxidoreductase; EC 1.1.1.62Chromosomal Location of Human Ortholog: 4q22.1Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lipid particleMolecular Function: estradiol 17-beta-dehydrogenase activity; steroid dehydrogenase activityBiological Process: androgen catabolic process; estrogen biosynthetic process
UniProt Protein Details:
NCBI Summary:
Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
