The HSD17B14 Polyclonal Antibody (PACO09808) is a valuable tool for researchers studying HSD17B14, an enzyme involved in steroid metabolism and potentially implicated in cancer progression. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the HSD17B14 protein, this antibody allows for the detection and analysis of HSD17B14 expression in various cell types, making it a versatile tool for studies in cancer biology and endocrinology.HSD17B14 is a key player in the biosynthesis and metabolism of steroid hormones, making it a potential target for therapeutic intervention in hormone-related diseases like breast cancer and prostate cancer.
Understanding the role of HSD17B14 in steroid hormone regulation and tumorigenesis is essential for the development of novel treatment strategies targeting this enzyme. Researchers can use the HSD17B14 Polyclonal Antibody to further investigate the function of HSD17B14 and its potential implications in cancer development and progression.
HSD17B14: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3- beta,17-beta-diol (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) family.Protein type: EC 1.1.1.-; OxidoreductaseChromosomal Location of Human Ortholog: 19q13.33Cellular Component: cytosolMolecular Function: estradiol 17-beta-dehydrogenase activity; identical protein binding; protein binding; testosterone 17-beta-dehydrogenase (NADP+) activityBiological Process: estrogen biosynthetic process; steroid catabolic process
UniProt Protein Details:
NCBI Summary:
17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]
17-beta-hydroxysteroid dehydrogenase DHRS10; Dehydrogenase/reductase SDR family member 10; Retinal short-chain dehydrogenase/reductase retSDR3; Short chain dehydrogenase/reductase family 47C member 1
