The HSD17B6 Polyclonal Antibody (CAB14474) is a valuable tool for researchers studying the HSD17B6 protein, a key enzyme involved in steroid hormone metabolism. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to HSD17B6, the antibody enables accurate detection and analysis of this important enzyme in a variety of cell types, making it an ideal choice for studies in endocrinology, reproductive biology, and cancer research.HSD17B6 plays a crucial role in the biosynthesis and metabolism of steroid hormones, making it a promising target for investigations into hormone-related disorders such as hormone-dependent cancers, polycystic ovary syndrome, and endocrine dysfunctions.
Understanding the functions and mechanisms of HSD17B6 can provide valuable insights into the development of new treatments and therapies for these conditions. The HSD17B6 Polyclonal Antibody is a valuable tool for researchers looking to deepen their understanding of steroid hormone metabolism and its implications for human health.
Product Name:
HSD17B6 Rabbit Polyclonal Antibody
SKU:
CAB14474
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 178-317 of human HSD17B6 (NP_003716.2).
Early endosome membrane, Lumenal side, Microsome membrane, Peripheral membrane protein.
Calculated MW:
36kDa
Observed MW:
36kDa
The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family.
Purification Method:
Affinity purification
Gene ID:
8630
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HSD17B6 Rabbit pAb (CAB14474) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
