The Human CD64 Monoclonal Antibody (PE-conjugated) is a specialized tool for research involving CD64, a cell surface molecule involved in immune responses. This antibody, derived from mouse monoclonal cells, is specifically reactive with human samples and is validated for use in flow cytometry applications. By binding to the CD64 protein, it allows for the detection and analysis of this molecule in various cell types, making it an important asset for studies in immunology and cancer research.
CD64, also known as Fc-gamma receptor I, plays a crucial role in mediating immune responses by binding to the Fc portion of immunoglobulins. Its involvement in antibody-dependent cellular cytotoxicity and phagocytosis make it a key player in the immune system's defense mechanisms. Research into CD64 is essential for understanding how immune cells combat infections and target cancer cells, leading to potential therapeutic interventions in infectious diseases and cancer treatment strategies.
Product Title:
PE Anti-Human CD64 Antibody [10.1]
SKU:
AGEL1114
Size:
20 Tests, 100 Tests, 200 Tests
Clone No:
10.1
Synonyms:
Fc fragment of IgG high affinity Ia/b/c receptor;CD64A/B/C;CD64;Fc gamma RI;FCGR1A/B/C;IGFR 1;
Host Species:
Mouse
Reactivity:
Human
Application:
FCM
Isotype:
Mouse IgG1, κ
Isotype Control:
PE Mouse IgG1, κ Isotype Control[MOPC-21]
Form:
Liquid
Conjugation:
PE
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P12314
Gene ID:
2209
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD64 is a 72 kD single chain type I glycoprotein also known as FcγRI and FcR I. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes. The expression can be upregulated by IFN-γ stimulation. CD64 binds IgG immune complex. It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC).
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