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Purified Anti-Human CD86 Antibody [BU63] (AGEL0092)

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SKU AGEL0092
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human
Host Species Mouse
Isotype IgG1
Clone BU63
Conjugation Unconjugated
Applications FC
Applications WB
Applications Block
Applications IP
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Description

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Purified Anti-Human CD86 Antibody [BU63]

The Human CD86 Monoclonal Antibody BU63 (AGEL0092) from Assay Genie is a valuable tool for researchers investigating the role of CD86 in immune cell activation and regulation. CD86, also known as B7-2, is a co-stimulatory molecule expressed on antigen-presenting cells that plays a crucial role in T cell activation and immune response modulation. The monoclonal antibody BU63 specifically targets CD86, allowing for precise detection and analysis in a variety of experimental settings.This high-quality antibody is well-suited for applications such as flow cytometry, immunofluorescence, and immunohistochemistry, providing researchers with a versatile tool for studying the function and expression of CD86 in different cell types and tissues.

By using the Human CD86 Monoclonal Antibody BU63 (AGEL0092), researchers can gain deeper insights into the complex mechanisms of immune activation and potential therapeutic targets for diseases such as autoimmune disorders, cancer, and inflammatory conditions. Its specificity and reliability make it an essential reagent for advancing immunology research and drug development.

Product Title:Purified Anti-Human CD86 Antibody [BU63]
SKU:AGEL0092
Size:25µg, 100µg
Clone No:BU63
Synonyms:T-lymphocyte activation antigen CD86;Cd86;Activation B7-2 antigen;Early T-cell costimulatory molecule 1;ETC-1;
Host Species:Mouse
Reactivity:Human
Application:FCM;Block
Isotype:Mouse IgG1, κ
Isotype Control:Purified Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P42081
Gene ID:942
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is the ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce costimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can bind to CD152 as well, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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