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Key Features

PE/Cyanine7 Anti-Human CD8a Antibody [OKT-8] (AGEL1391)

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SKU AGEL1391
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Human
Host Species Mouse
Isotype IgG2a,k
Clone OKT-8
Conjugation PE/Cy7
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Description

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PE/Cyanine7 Anti-Human CD8a Antibody [OKT-8]

The Human CD8a Monoclonal Antibody (PE/Cyanine7 Conjugated, OKT-8) is a highly specific and validated tool designed for flow cytometry applications targeting CD8a, a critical cell surface marker associated with cytotoxic T cells. This antibody, conjugated with PE/Cyanine7 for fluorescent detection, offers exceptional sensitivity and specificity in identifying CD8a-expressing cells in human samples.CD8a, a coreceptor on cytotoxic T cells, plays a crucial role in immune response by recognizing antigens presented on major histocompatibility complex (MHC) class I molecules. Its expression is indicative of cytotoxic T cell activation and function, making it a key marker for studying T cell-mediated immune responses in various research contexts, including immunology, infectious diseases, and cancer immunotherapy.

By utilizing the Human CD8a Monoclonal Antibody (PE/Cyanine7 Conjugated, OKT-8), researchers can accurately identify and quantify CD8a-positive cells within complex cell populations, providing valuable insights into T cell biology, immune activation, and disease pathogenesis. This antibody is a valuable tool for investigating the role of CD8a in adaptive immunity and for understanding the dynamics of T cell populations in health and disease settings.

Product Title:PE/Cyanine7 Anti-Human CD8a Antibody [OKT-8]
SKU:AGEL1391
Size:20 Tests, 100 Tests, 200 Tests
Clone No:OKT-8
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PE/Cyanine7 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P01732
Gene ID:925
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

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