Description
system_update_altDatasheet
| Product name | Human CMKLR1 full length protein-synthetic nanodisc |
| Size: | 10ug |
| Product SKU: | HDFP107 |
| Product Category | Full Length Transmembrane Proteins |
| Target: | CMKLR1 |
| Uniprot: | Q99788 |
| Description: | Human CMKLR1 full length protein-synthetic nanodisc |
| Molecular Weight: | The human full length CMKLR1 protein has a MW of 42.1 kDa |
| Protein Family: | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways: | |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Synonyms: | CHEMERINR; ChemR23; DEZ; RVER1 |
| Expression System: | HEK293 |
| Formulation: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| Background: | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).[UniProtKB/Swiss-Prot Function] |
| Delivery: | 3-4 weeks |
| Usage | Research use only |
