Description
| Product Name: | Nanodisc Human DRD2-Strep Protein |
| SKU: | HDFP958 |
| Size: | 10μg |
| Target: | DRD2 |
| Tag: | C-Flag&Strep Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | D2DR; D2R |
| Protein Families: | Druggable Genome, GPCR, Transmembrane. |
| Protein Description: | Human DRD2-Strep full length protein-synthetic nanodisc |
| Protein Pathways: | Gap junction, Neuroactive ligand-receptor interaction. |
| Molecular Weight: | The human full length DRD2-Strep protein has a MW of 50.6 kDa |
This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
| Uniprot ID: | P14416 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
