Human DTYMK Recombinant Protein (RPPB2499)
- SKU:
- RPPB2499
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P23919
- Research Area:
- Enzymes
Description
| Product Name: | Human DTYMK Recombinant Protein |
| Product Code: | RPPB2499 |
| Size: | 20µg |
| Species: | Human |
| Target: | DTYMK |
| Synonyms: | DeoxythymidylateKinase (Thymidylate Kinase), DTMP Kinase, CDC8, TMPK, TYMK, Thymidylate (DTMP)Kinase, EC 2.7.4.9, PP3731, Thymidylate kinase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | DTYMKprotein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 20%glycerol, 2mM DTT and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSHMAARRGALIV LEGVDRAGKS TQSRKLVEAL CAAGHRAELL RFPERSTEIG KLLSSYLQKK SDVEDHSVHLLFSANRWEQV PLIKEKLSQG VTLVVDRYAF SGVAFTGAKE NFSLDWCKQP DVGLPKPDLV LFLQLQLADAAKRGAFGHER YENGAFQERA LRCFHQLMKD TTLNWKMVDA SKSIEAVHED IRVLSEDAIR TATEKPLGEL WK |
Thymidylate kinase (DTYMK) is involved in pyrimidine metabolism. Specifically, DTYMK catalyzes the ATP-dependent conversion of dTMP (deoxythymidine monophosphate) to dTDP (deoxythymidine diphosphate), which then acts as one of the 4 nucleotides in DNA. Through its role in the catalytic creation of dTDP, DTYMK has an imperative role in the pathway of DNA synthesis and is assumed to be involved in cell cycle progression and cell growth.
DTYMK Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 232 amino acids (1-212 a.a) andhaving a molecular mass of 26kDa.DTYMK is fused to a 20amino acid His-tag at N-terminus & purified by proprietary chromatographictechniques.
| UniProt Protein Function: | DTYMK: Catalyzes the conversion of dTMP to dTDP. Belongs to the thymidylate kinase family. |
| UniProt Protein Details: | Protein type:EC 2.7.4.9; Mitochondrial; Kinase, other; Nucleotide Metabolism - pyrimidine Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: cytosol; mitochondrion; nucleus Molecular Function:nucleoside phosphate kinase activity; thymidylate kinase activity; uridylate kinase activity Biological Process: cell cycle; cell proliferation; dTDP biosynthetic process; dTTP biosynthetic process; dUDP biosynthetic process; nucleobase, nucleoside and nucleotide interconversion |
| UniProt Code: | P23919 |
| NCBI GenInfo Identifier: | 56405325 |
| NCBI Gene ID: | 1841 |
| NCBI Accession: | P23919.4 |
| UniProt Secondary Accession: | P23919,Q6FGX1, Q9BUX4, B7ZW70, |
| UniProt Related Accession: | P23919 |
| Molecular Weight: | 21,064 Da |
| NCBI Full Name: | Thymidylate kinase |
| NCBI Synonym Full Names: | deoxythymidylate kinase |
| NCBI Official Symbol: | DTYMK�� |
| NCBI Official Synonym Symbols: | CDC8; TMPK; TYMK; PP3731�� |
| NCBI Protein Information: | thymidylate kinase |
| UniProt Protein Name: | Thymidylate kinase |
| UniProt Synonym Protein Names: | dTMP kinase |
| UniProt Gene Name: | DTYMK�� |
| UniProt Entry Name: | KTHY_HUMAN |
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