Human FGF12 Recombinant Protein (RPPB0225)
- SKU:
- RPPB0225
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P61328
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human FGF12 Recombinant Protein |
| Product Code: | RPPB0225 |
| Size: | 10µg |
| Species: | Human |
| Target: | FGF12 |
| Synonyms: | FGF-12, FGF12, FGF12B, FHF1, Fibroblast growth factor 12, Fibroblast growth factor homologous factor 1, FHF-1, Myocyte-activating factor. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile liquid colorless solution. |
| Formulation: | The FGF-12 solution (1mg/ml) contains 20mM Tris pH-7.5, 1mM DTT, 2mM EDTA and 10% glycerol. |
| Stability: | Store FGF12 at -20°C. Can be stored at 4°C for a limited period of time of 7 days. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MSSHHHHHH SSGLVPRGSH MESKEPQLKG IVTRLFSQQG YFLQMHPDGT IDGTKDENSD YTLFNLIPVG LRVVAIQGVK ASLYVAMNGE YLYSSDVFT PECKFKESVF ENYYVIYSST LYRQQESGRA WFLGLNKEGQ IMKGNRVKKT KPSSHFVPKP IEVCMYREQS LHEIGEKQGR RKSSGTPTM NGGKVVNQDS T |
FGF12 is part of the Fibroblast Growth Factor (FGF) family which has a vast mitogenic and cell survival functions, and play a role in a range of biological activities, among them are embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF-12 doesn�t obtain the N-terminal signal sequence present in the majority of the FGF family members, but it contains clusters of basic residues that act as a nuclear localization signal. When transfected into mammalian cells, FGF12 accumulated in the nucleus, but was not secreted. FGF12 is involved in nervous system development and function. FGF12 binds to IB2 (islet brain-2), a cellular kinase scaffold, and voltage gated sodium channels and is also involved in intracellular signaling and ion exchange.
The FGF-12 Human recombinant protein is a single, non-glycosylated polypeptide chain produced in E. coli, having a molecular weight of 22.6kDa and containing 201 amino acids (1-181). The FGF12 is fused to a 20 amino acid His tag at the N-terminus.
| UniProt Protein Function: | FGF12: Probably involved in nervous system development and function. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Cytokine Chromosomal Location of Human Ortholog: 3q28 Cellular Component: extracellular space; intracellular; nucleus Molecular Function:fibroblast growth factor receptor binding; growth factor activity; heparin binding; protein binding; sodium channel regulator activity Biological Process: adult locomotory behavior; cell-cell signaling; fibroblast growth factor receptor signaling pathway; heart development; JNK cascade; nervous system development; neuromuscular process; signal transduction; synaptic transmission |
| NCBI Summary: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P61328 |
| NCBI GenInfo Identifier: | 47117683 |
| NCBI Gene ID: | 2257 |
| NCBI Accession: | P61328.1 |
| UniProt Secondary Accession: | P61328,O35339, P70376, Q8TBG5, Q92912, Q93001, B2R6B7 B2R976, |
| UniProt Related Accession: | P61328 |
| Molecular Weight: | 20,424 Da |
| NCBI Full Name: | Fibroblast growth factor 12 |
| NCBI Synonym Full Names: | fibroblast growth factor 12 |
| NCBI Official Symbol: | FGF12�� |
| NCBI Official Synonym Symbols: | FHF1; FGF12B�� |
| NCBI Protein Information: | fibroblast growth factor 12 |
| UniProt Protein Name: | Fibroblast growth factor 12 |
| UniProt Synonym Protein Names: | Fibroblast growth factor homologous factor 1; FHF-1; Myocyte-activating factor |
| Protein Family: | Fibroblast growth factor |
| UniProt Gene Name: | FGF12�� |
| UniProt Entry Name: | FGF12_HUMAN |
