Description
| Product Name: | Nanodisc Human GNRHR-Strep Protein |
| SKU: | HDFP829 |
| Size: | 10μg |
| Target: | GNRHR |
| Tag: | C-Flag&Strep Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | GNRHR1; GRHR; HH7; LHRHR; LRHR |
| Protein Families: | Druggable Genome, GPCR, Transmembrane. |
| Protein Description: | Human GNRHR-Strep full length protein-synthetic nanodisc |
| Protein Pathways: | GnRH signaling pathway, Neuroactive ligand-receptor interaction. |
| Molecular Weight: | The human full length GNRHR-Strep protein has a MW of 37.7 kDa |
The receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms.
| Uniprot ID: | P30968 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
