Description
| Product Name: | Nanodisc Human HCAR3-Strep Protein |
| SKU: | HDFP1053 |
| Size: | 10μg |
| Target: | HCAR3 |
| Tag: | C-Flag&Strep Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | GPR109B, HCA3, HM74, PUMAG, Puma-g |
| Protein Families: | GPCR, Transmembrane, Druggable Genome. |
| Protein Description: | Human HCAR3-Strep full length protein-synthetic nanodisc |
| Protein Pathways: | Chemokines, Chemokine and Receptor, G-Protein Coupled Receptors Signaling Pathway. |
| Molecular Weight: | The human full length HCAR3-Strep protein has a MW of 44.5 kDa |
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.[UniProtKB/Swiss-Prot Function]
| Uniprot ID: | P49019 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
