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PE Anti-Human/Mouse/Rat CD47 Antibody [MIAP410] (AGEL0680)

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SKU AGEL0680
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Human
Reactivity Mouse
Reactivity Rat
Host Species Mouse
Isotype IgG2a,k
Clone MIAP410
Conjugation PE
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Description

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PE Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]

The Human/Mouse/Rat CD47 Monoclonal Antibody (PE Conjugated) (MIAP410) is a powerful tool for researchers studying CD47, a cell surface protein known for its role in immune evasion and cancer progression. This monoclonal antibody, conjugated to phycoerythrin (PE), offers reliable and sensitive detection of CD47 in human, mouse, and rat samples across a variety of experimental techniques.CD47, a widely studied "don't eat me" signal, is implicated in multiple cellular processes, including the regulation of phagocytosis, apoptosis, and cell migration. Its overexpression in tumors enables cancer cells to evade immune surveillance, making it an attractive target for immunotherapy research.

By specifically recognizing and binding to CD47, this antibody facilitates precise visualization and quantification of CD47 expression in diverse cell types, supporting investigations in immunology, oncology, and beyond.With its validated performance and versatility in applications such as flow cytometry and immunofluorescence, the Human/Mouse/Rat CD47 Monoclonal Antibody (PE Conjugated) (MIAP410) is an essential reagent for scientists seeking to unravel the complexities of CD47 biology and its therapeutic implications in diseases like cancer and autoimmune disorders.

Product Title:PE Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]
SKU:AGEL0680
Size:25µg, 100µg
Clone No:MIAP410
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human;Mouse;Rat
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q08722 Q61735 P97829
Gene ID:961,16423,29364
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. It is widely expressed on many cell types and often associated with beta 3 integrins. It has been reported that CD47 functions as a self marker. Red cells lacking CD47 were rapidly cleared from the bloodstream by splenic macrophages. By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking.

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