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Key Features

PerCP/Cyanine5.5 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410] (AGEL0686)

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SKU AGEL0686
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Human
Reactivity Mouse
Reactivity Rat
Host Species Mouse
Isotype IgG2a,k
Clone MIAP410
Conjugation PerCP/Cy5.5
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Description

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PerCP/Cyanine5.5 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]

The CD47 Monoclonal Antibody (PERCP-Cyanine5.5 Conjugated, MIAP410) is a cutting-edge tool for researchers in the fields of immunology and cancer biology. This antibody, which specifically targets CD47—a cell surface protein involved in immune evasion and self-recognition mechanisms—is a key player in the regulation of immune responses and the prevention of phagocytosis by macrophages.With its high specificity and reactivity towards human, mouse, and rat samples, this monoclonal antibody opens up new possibilities for studying the role of CD47 in various biological processes. Its PERCP-Cyanine5.5 conjugation allows for easy and efficient flow cytometry analysis, offering detailed insights into the expression levels and localization of CD47 in different cell types and tissues.

In cancer research, the CD47 Monoclonal Antibody can provide valuable information on how tumors escape immune surveillance and how CD47-targeted therapies may enhance anti-tumor immune responses. Furthermore, its potential to modulate immune checkpoints and promote anti-cancer immunity makes it a promising candidate for the development of novel immunotherapies.Whether investigating immune evasion mechanisms in cancer, autoimmune disorders, or other pathological conditions, the CD47 Monoclonal Antibody (PERCP-Cyanine5.5 Conjugated, MIAP410) is a versatile and reliable tool that can drive impactful discoveries in immunology and oncology research.

Product Title:PerCP/Cyanine5.5 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]
SKU:AGEL0686
Size:25µg, 100µg
Clone No:MIAP410
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human;Mouse;Rat
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PerCP/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q08722 Q61735 P97829
Gene ID:961,16423,29364
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. It is widely expressed on many cell types and often associated with beta 3 integrins. It has been reported that CD47 functions as a self marker. Red cells lacking CD47 were rapidly cleared from the bloodstream by splenic macrophages. By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking.

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