Human NANP Recombinant Protein (RPPB1996)
- SKU:
- RPPB1996
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8TBE9
- Research Area:
- Enzymes
Description
| Product Name: | Human NANP Recombinant Protein |
| Product Code: | RPPB1996 |
| Size: | 20µg |
| Species: | Human |
| Target: | NANP |
| Synonyms: | N-acylneuraminate-9-phosphatase, Haloacid dehalogenase-like hydrolase domain-containing protein 4, Neu5Ac-9-Pase, NANP, HDHD4, MGC26833, C20orf147, dJ694B14.3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The NANP solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 2mM DTT and 100mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMGLS RVRAVFFDLD NTLIDTAGAS RRGMLEVIKL LQSKYHYKEE AEIICDKVQV KLSKECFHPY NTCITDLRTS HWEEAIQETK GGAANRKLAE ECYFLWKSTR LQHMTLAEDV KAMLTELRKE VRLLLLTNGD RQTQREKIEA CACQSYFDAV VVGGEQREEK PAPSIFYYCC NLLGVQPGDC VMVGDTLETD IQGGLNAGLK ATVWINKNGI VPLKSSPVPH YMVSSVLELP ALLQSIDCKV SMST |
N-acylneuraminate-9-phosphatase (NANP) belongs to the haloacid dehalogenase (HAD) family and is responsible for dephosphorylating N-acylneuraminate 9-phosphate to form N-acylneuraminate (N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate). The catalytic activity of NANP is relies on the presence of magnesium and is inhibited by vanadate and calcium, which is typical of the HAD phosphatase family.
NANP Human Recombinant fused with a 36 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 284 amino acids (1-248 a.a.) and having a molecular mass of 31.9kDa. The NANP is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HDHD4: Belongs to the HAD-like hydrolase superfamily. NANP family. |
| UniProt Protein Details: | Protein type:EC 3.1.3.29; Phosphatase (non-protein); Carbohydrate Metabolism - amino sugar and nucleotide sugar Chromosomal Location of Human Ortholog: 20p11.1 Cellular Component: cytosol Molecular Function:N-acylneuraminate-9-phosphatase activity Biological Process: N-acetylglucosamine biosynthetic process; N-acetylneuraminate biosynthetic process; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; dephosphorylation; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification |
| UniProt Code: | Q8TBE9 |
| NCBI GenInfo Identifier: | 23308749 |
| NCBI Gene ID: | 140838 |
| NCBI Accession: | NP_689880.1 |
| UniProt Secondary Accession: | Q8TBE9,Q5JYN8, Q8TE97, Q9Y3N0, B3KP12, |
| UniProt Related Accession: | Q8TBE9 |
| Molecular Weight: | 27,813 Da |
| NCBI Full Name: | N-acylneuraminate-9-phosphatase |
| NCBI Synonym Full Names: | N-acetylneuraminic acid phosphatase |
| NCBI Official Symbol: | NANP�� |
| NCBI Official Synonym Symbols: | HDHD4; C20orf147; dJ694B14.3�� |
| NCBI Protein Information: | N-acylneuraminate-9-phosphatase |
| UniProt Protein Name: | N-acylneuraminate-9-phosphatase |
| UniProt Synonym Protein Names: | Haloacid dehalogenase-like hydrolase domain-containing protein 4; Neu5Ac-9-Pase |
| Protein Family: | N-acylneuraminate-9-phosphatase |
| UniProt Gene Name: | NANP�� |
| UniProt Entry Name: | NANP_HUMAN |
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