Description
| Product Name: | Human PEF1 Recombinant Protein |
| Product Code: | RPPB4223 |
| Size: | 10µg |
| Species: | Human |
| Target: | PEF1 |
| Synonyms: | Peflin, PEF protein with a long N-terminal hydrophobic domain, Penta-EF hand domain-containing protein 1, PEF1, ABP32, PEF1A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PEF1 solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 50% glycerol and 0.2M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASY PYRQGCPGAA GQAPGAPPGSYYPGPPNSGG QYGSGLPPGG GYGGPAPGGP YGPPAGGGPY GHPNPGMFPS GTPGGPYGGAAPGGPYGQPP PSSYGAQQPG LYGQGGAPPN VDPEAYSWFQ SVDSDHSGYI SMKELKQALVNCNWSSFNDE TCLMMINMFD KTKSGRIDVY GFSALWKFIQ QWKNLFQQYD RDRSGSISYTELQQALSQMG YNLSPQFTQL LVSRYCPRSA NPAMQLDRFI QVCTQLQVLT EAFREKDTAVQGNIRLSFED FVTMTASRML |
Penta-EF-hand domain containing 1 (PEF1) is a member of the penta-EF-hand protein family, which shares similarities to the apoptosis linked gene ALG-2. PEF1 forms heterodimers with PDCD6/ALG2 and dissociates from PDCD6/ALG2 in the presence of Ca (2+). Furthermore, PEF1 proteins bind calcium and participate in a various calcium-dependent processes in vertebrates.
PEF1 Human Recombinant fused with a�36 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�320 amino acids (1-284 a.a.) and having a molecular mass of 34.5kDa. The PEF1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PEF1: Heterodimer; heterodimerizes with PDCD6/ALG2. Dissociates from PDCD6/ALG2 in presence of Ca(2+). |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1p34 Cellular Component: membrane; cytoplasm Molecular Function:protein dimerization activity; protein binding; protein heterodimerization activity; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding Biological Process: proteolysis; response to calcium ion |
| NCBI Summary: | This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. The encoded protein has been shown to form a heterodimer with the programmed cell death 6 gene product and may modulate its function in Ca(2+) signaling. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 1.[provided by RefSeq, May 2010] |
| UniProt Code: | Q9UBV8 |
| NCBI GenInfo Identifier: | 74761895 |
| NCBI Gene ID: | 553115 |
| NCBI Accession: | Q9UBV8.1 |
| UniProt Related Accession: | Q9UBV8 |
| Molecular Weight: | 30,381 Da |
| NCBI Full Name: | Peflin |
| NCBI Synonym Full Names: | penta-EF-hand domain containing 1 |
| NCBI Official Symbol: | PEF1�� |
| NCBI Official Synonym Symbols: | ABP32; PEF1A�� |
| NCBI Protein Information: | peflin; PEF protein with a long N-terminal hydrophobic domain; penta-EF hand domain containing 1 |
| UniProt Protein Name: | Peflin |
| UniProt Synonym Protein Names: | PEF protein with a long N-terminal hydrophobic domain; Penta-EF hand domain-containing protein 1 |
| Protein Family: | Peflin |
| UniProt Gene Name: | PEF1�� |
| UniProt Entry Name: | PEF1_HUMAN |
