Description
| Product Name: | Nanodisc Human TLR5-Strep Protein |
| SKU: | HDFP879 |
| Size: | 10μg |
| Target: | TLR5 |
| Tag: | C-Flag&Strep Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | MELIOS; SLE1; SLEB1; TIL3 |
| Protein Families: | Druggable Genome, Transmembrane. |
| Protein Description: | Human TLR5-Strep full length protein-synthetic nanodisc |
| Protein Pathways: | Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway. |
| Molecular Weight: | The human full length TLR5-Strep protein has a MW of 97.8 kDa |
Toll-like receptor (TLR) family plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
| Uniprot ID: | O60602 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
