Human TNFRSF17 Recombinant Protein (RPPB1040)
- SKU:
- RPPB1040
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q02223
- Research Area:
- Cytokines
Frequently bought together:
Description
| Product Name: | Human TNFRSF17 Recombinant Protein |
| Product Code: | RPPB1040 |
| Size: | 10µg |
| Species: | Human |
| Target: | TNFRSF17 |
| Synonyms: | BCMA, CD269, Tumor Necrosis Factor Receptor Superfamily Member 17, BCM, TNFRSF17, B-cell maturation protein, CD269 antigen |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TNFRSF17 protein (0.5mg/ml) contains 10% glycerol and Phosphate-Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPMLQMAGQ CSQNEYFDSL LHACIPCQLR CSSNTPPLTC QRYCNASVTN SVKGTNALEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH |
B-Cell Maturation Antigen or TNFRSF17 or tumor necrosis factor receptor superfamily member 17, is part of the TNF receptor protein family. This protein is a TNFSF13B/BLyS/BAFF, TNFSF13/APRIL & promotes B-cell survival receptor. TNFRSF17 has a crucial part in the humoral immunity regulation. This protein is responsible for the activation of NF-kappa-B & JNK.
TNFRSF17 Human Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 296 amino acids (1-54 aa) and having a molecular mass of �33.1Da.TNFRSF17 is fused to a 242 amino acid hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.Protein type: Oncoprotein; Receptor, misc.; Membrane protein, integralChromosomal Location of Human Ortholog: 16p13.1Cellular Component: endomembrane system; integral to membrane; plasma membraneMolecular Function: receptor activityBiological Process: adaptive immune response; cell proliferation; lymphocyte homeostasis; multicellular organismal development; signal transduction; tumor necrosis factor-mediated signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q02223 |
| NCBI GenInfo Identifier: | 313104029 |
| NCBI Gene ID: | 608 |
| NCBI Accession: | Q02223.2 |
| UniProt Secondary Accession: | Q02223,Q2TQ40 |
| UniProt Related Accession: | Q02223 |
| Molecular Weight: | 14,843 Da |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 17 |
| NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily member 17 |
| NCBI Official Symbol: | TNFRSF17�� |
| NCBI Official Synonym Symbols: | BCM; BCMA; CD269; TNFRSF13A�� |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 17 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 17 |
| UniProt Synonym Protein Names: | B-cell maturation protein; CD_antigen: CD269 |
| Protein Family: | |
| UniProt Gene Name: | TNFRSF17�� |
| UniProt Entry Name: | TNR17_HUMAN |
