Description
| Product Name: | Nanodisc Human TSHR-Strep Protein |
| SKU: | HDFP787 |
| Size: | 10μg |
| Target: | TSHR |
| Tag: | C-Flag&Strep Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | CHNG1; hTSHR-I; LGR3 |
| Protein Families: | Druggable Genome, GPCR, Transmembrane. |
| Protein Description: | Human TSHR-Strep full length protein-synthetic nanodisc |
| Protein Pathways: | Autoimmune thyroid disease, Neuroactive ligand-receptor interaction. |
| Molecular Weight: | The human full length TSHR-Strep protein has a MW of 86.8 kDa |
The protein is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism.
| Uniprot ID: | P16473 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
