Human UBE2G2 Recombinant Protein (RPPB2377)
- SKU:
- RPPB2377
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P60604
- Research Area:
- Enzymes
Description
| Product Name: | Human UBE2G2 Recombinant Protein |
| Product Code: | RPPB2377 |
| Size: | 20µg |
| Species: | Human |
| Target: | UBE2G2 |
| Synonyms: | Ubiquitin-conjugating enzyme E2 G2, E2 ubiquitin-conjugating enzyme G2, Ubiquitin carrier protein G2, Ubiquitin-protein ligase G2, UBE2G2, Ubiquitin-Conjugating Enzyme E2G2, Ubiquitin-conjugating enzyme E2 G2 isoform 1, UBC7. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | UBE2G2 protein solution (1mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAGTALK RLMAEYKQLT LNPPEGIVAG PMNEENFFEW EALIMGPEDT CFEFGVFPAI LSFPLDYPLS PPKMRFTCEM FHPNIYPDGR VCISILHAPG DDPMGYESSA ERWSPVQSVE KILLSVVSML AEPNDESGAN VDASKMWRDD REQFYKIAKQ IVQKSLGL |
Ubiquitin-Conjugating Enzyme E2G2 (UBE2G2) is a protein coding gene which is a part of the E2 ubiquitin-conjugating enzyme family. UBE2G2 accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to various proteins. UBE2G2 is ubiquitously expressed mainly in adult muscle. UBE2G2 also takes part in endoplasmic reticulum-associated degradation (ERAD).
UBE2G2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 188 amino acids (1-165a.a.) and having a molecular mass of 21kDa.UBE2G2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | UBE2G2: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD). Belongs to the ubiquitin-conjugating enzyme family. |
| UniProt Protein Details: | Protein type:EC 6.3.2.19; Endoplasmic reticulum; Ligase; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: cytosol Molecular Function:protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity Biological Process: cellular protein catabolic process; ER-associated protein catabolic process; protein amino acid N-linked glycosylation via asparagine; protein ubiquitination; ubiquitin-dependent protein catabolic process |
| NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011] |
| UniProt Code: | P60604 |
| NCBI GenInfo Identifier: | 45593583 |
| NCBI Gene ID: | 7327 |
| NCBI Accession: | P60604.1 |
| UniProt Secondary Accession: | P60604,P56554, A6NMQ7, A8K3L4, D3DSL7, |
| UniProt Related Accession: | P60604 |
| Molecular Weight: | 19kDa |
| NCBI Full Name: | Ubiquitin-conjugating enzyme E2 G2 |
| NCBI Synonym Full Names: | ubiquitin conjugating enzyme E2 G2 |
| NCBI Official Symbol: | UBE2G2�� |
| NCBI Official Synonym Symbols: | UBC7�� |
| NCBI Protein Information: | ubiquitin-conjugating enzyme E2 G2 |
| UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 G2 |
| UniProt Synonym Protein Names: | E2 ubiquitin-conjugating enzyme G2; Ubiquitin carrier protein G2; Ubiquitin-protein ligase G2 |
| Protein Family: | Ubiquitin-conjugating enzyme |
| UniProt Gene Name: | UBE2G2�� |
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