The IFNT1 Polyclonal Antibody (PAC034262) is a valuable tool for researchers studying IFNT1, an important factor in embryonic implantation and pregnancy maintenance in mammals. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications including Western blotting.IFNT1, also known as Interferon Tau, is a type I interferon that is primarily expressed in ruminant ungulates during early pregnancy. Its expression plays a crucial role in regulating the maternal immune system and promoting embryo implantation and placental development.
Research on IFNT1 is essential for understanding the mechanisms underlying successful pregnancy outcomes in livestock and potentially in humans as well.By using the IFNT1 Polyclonal Antibody, researchers can accurately detect and analyze IFNT1 protein levels in different cell types and tissues, advancing our knowledge of reproductive biology and potentially leading to the development of new therapies for infertility and pregnancy-related disorders. This antibody is a valuable resource for studies focused on reproductive immunology and fertility research.
Antibody Name:
IFNT1 Antibody (PACO34262)
Antibody SKU:
PACO34262
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Bovine
Immunogen:
Recombinant Bovine Interferon tau-1 protein (24-195AA)
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
