The IGSF10 Monoclonal Antibody (PAC014563) is a valuable tool for researchers studying IGSF10, a cell surface molecule associated with immune regulation and cell-cell adhesion. This antibody, produced in a monoclonal mouse system, is highly specific to human samples and has been validated for use in immunohistochemistry applications. By binding to the IGSF10 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for studies in immunology and cancer research.
IGSF10, also known as immunoglobulin superfamily member 10, plays a crucial role in immune system function by mediating cell-cell interactions and modulating immune responses. Its involvement in immune regulation suggests its potential as a target for therapeutics in diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the role of IGSF10 is essential for developing treatments that can manipulate immune function for therapeutic benefit in these contexts.
Antibody Name:
IGSF10 Antibody (PACO14563)
Antibody SKU:
PACO14563
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Fusion protein of human IGSF10
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO14563(IGSF10 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14563(IGSF10 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Ig (immunoglobulin) superfamily members exhibit functional characteristics including immune responses, growth factor signaling and cell adhesion. IGSF10 (immunoglobulin superfamily, member 10), also known as Calvaria mechanical force protein 608 (CMF608), is a 2,623 amino acid, secreted protein that contains an N-terminal signal peptide, six leucine-rich repeats (LRRs), and 12 immunoglobulin-like repeats. IGSF10 exists as multiple alternatively spliced isoforms, and is expressed in bone. Specifically, expression of IGSF10 is limited to mesenchymal osteochondroprogenitors with fibroblast-like morphology, where it is thought to be involved in the maintenance of the osteochondroprogenitor cells pool and its down-regulation precedes terminal differentiation.
Synonyms:
immunoglobulin superfamily, member 10
UniProt Protein Function:
IGSF10: May be involved in the maintenance of osteochondroprogenitor cells pool. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Immunoglobulin superfamily; Secreted, signal peptide; Protein kinase, tyrosine (receptor); Kinase, protein; SecretedChromosomal Location of Human Ortholog: 3q25.1Cellular Component: extracellular regionBiological Process: ossification; multicellular organismal development; cell differentiation
