The IL17RA Monoclonal Antibody (CAB5163) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, is highly specific for the IL-17A receptor and has been validated for use in various applications including Western blotting.The IL-17A receptor is known to be involved in various inflammatory conditions and autoimmune diseases, making it a promising target for therapeutic interventions. By using this antibody, researchers can effectively detect and analyze the IL-17A receptor in different cell types, providing valuable insights into its role in disease pathogenesis.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.
Product Name:
IL17RA Monoclonal Antibody
SKU:
CAB5163
Size:
20μL, 100μL
Reactivity:
Mouse, Rat
Clone Number:
ARC1240
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Membrane, Secreted, Single-Pass Type I Membrane Protein.
Calculated MW:
96kDa
Observed MW:
120kDa
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method
Affinity purification
Gene ID
23765
RRID
AB_2863470
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using IL17RA Rabbit mAb (CAB5163) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
