null

Anti-IL-37 Antibody (CAB8206)

SKU:
CAB8206
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-IL-37 Antibody
Antibody SKU:CAB8206
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human IL37 (NP_055254.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:Raji, A-549
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human IL37 (NP_055254.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSFV GENS GVKM GSED WEKD EPQC CLED PAGS PLEP GPSL PTMN FVHT SPKV KNLN PKKF SIHD QDHK VLVL DSGN LIAV PDKN YIRP EIFF ALAS SLSS ASAE KGSP ILLG VSKG EFCL YCDK DKGQ SHPS LQLK KEKL MKLA AQKE SARR PFIF YRAQ VGSW NMLE SAAH PGWF ICTS CNCN EPVG VTDK FENR KHIE FSFQ PVCK AEMS PSEV SD
Gene ID:27178
Uniprot:Q9NZH6
Cellular Location:Cytoplasm, Nucleus, Secreted, cytosol
Calculated MW:17kDa/19kDa/21kDa/24kDa
Observed MW:24kDa
Synonyms:IL37, FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1
Background:The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.
UniProt Protein Function:IL37: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. Belongs to the IL-1 family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytokine

Chromosomal Location of Human Ortholog: 2q12-q14.1

Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space; nucleolus; nucleus

Molecular Function:cytokine activity; interleukin-1 receptor binding

Biological Process: cytokine and chemokine mediated signaling pathway; immune response; inflammatory response to antigenic stimulus

NCBI Summary:The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NZH6
NCBI GenInfo Identifier:25008593
NCBI Gene ID:27178
NCBI Accession:Q9NZH6.1
UniProt Secondary Accession:Q9NZH6,Q56AP9, Q8TD04, Q8TD05, Q9HBF2, Q9HBF3, Q9UHA6 B5BU97,
UniProt Related Accession:Q9NZH6
Molecular Weight:17,459 Da
NCBI Full Name:Interleukin-37
NCBI Synonym Full Names:interleukin 37
NCBI Official Symbol:IL37  
NCBI Official Synonym Symbols:FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)  
NCBI Protein Information:interleukin-37
UniProt Protein Name:Interleukin-37
UniProt Synonym Protein Names:FIL1 zeta; IL-1X; Interleukin-1 family member 7; IL-1F7; Interleukin-1 homolog 4; IL-1H; IL-1H4; Interleukin-1 zeta; IL-1 zeta; Interleukin-1-related protein; IL-1RP1; Interleukin-23; IL-37
Protein Family:Interleukin
UniProt Gene Name:IL37  
UniProt Entry Name:IL37_HUMAN
Anti-IL-37 Antibody (CAB8206)Western blot - IL-37 Polyclonal Antibody (CAB8206)

Related Products