The Anti-IL15 Antibody (CAB19319) is a high-quality polyclonal antibody designed for research involving IL-15, a pro-inflammatory cytokine that plays a key role in immune response. This antibody, raised in rabbits, shows high reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.IL-15 is known for its role in promoting the proliferation and activation of natural killer cells and CD8+ T cells, making it a crucial mediator in the immune response to infections and tumors.
Studies have also shown its involvement in the pathogenesis of autoimmune diseases and inflammatory disorders. The Anti-IL15 Antibody facilitates the detection and analysis of IL-15 in different cell types, making it an essential tool for research in immunology, oncology, and autoimmune disease.
Product Name:
IL15 Rabbit Polyclonal Antibody
SKU:
CAB19319
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human IL15 (NP_000576.1).
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.
Purification Method:
Affinity purification
Gene ID:
3600
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IL15 Rabbit pAb (CAB19319) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
