Description
IL21R Antibody (CAB7468)
The IL21R Antibody (CAB7468) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is specifically designed for use in various applications, including Western blotting, immunohistochemistry, and flow cytometry.IL-21R plays a key role in modulating immune responses, particularly in the regulation of T and B cell function. Its dysregulation has been implicated in various immune-related disorders, making it a promising target for therapeutic intervention.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
| Product Name: | IL21R Antibody |
| SKU: | CAB7468 |
| Size: | 20μL, 100μL |
| Reactivity: | Human, Mouse |
| Conjugate: | Unconjugated |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. | ||||
| Sequence: | GVSM PRGW AAPL LLLL LQGG WGCP DLVC YTDY LQTV ICIL EMWN LHPS TLTL TWQD QYEE LKDE ATSC SLHR SAHN ATHA TYTC HMDV FHFM ADDI FSVN ITDQ SGNY SQEC GSFL LAES IKPA PPFN VTVT FSGQ YNIS WRSD YEDP AFYM LKGK LQYE LQYR NRGD PWAV SPRR KLIS VDSR SVSL LPLE FRKD SSYE LQVR AGPM PGSS YQGT WSEW S | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | NILR, CD360, IMD56, IL21R |
| Positive Sample: | U-87MG, Mouse spleen, Mouse thymus |
| Cellular Localization: | Membrane, Single-Pass Type I Membrane Protein. |
| Calculated MW: | 59kDa |
| Observed MW: | 70kDa |
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
| Purification Method | Affinity purification |
| Gene ID | 50615 |
| RRID | AB_2767999 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3. |
 | Western blot analysis of various lysates using IL21R Rabbit pAb (CAB7468) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s. |
