The IL36RN Polyclonal Antibody (CAB8205) is a valuable tool for researchers studying IL36RN, a key player in the IL-36 cytokine family known for its role in skin inflammation and immune response regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications including Western blot and immunohistochemistry.IL36RN, also known as Interleukin 36 receptor antagonist, functions as a negative regulator of the IL-36 signaling pathway, which is essential for maintaining immune homeostasis and preventing excessive inflammation.
Dysregulation of this pathway has been linked to various inflammatory skin diseases, such as psoriasis.By targeting IL36RN with this polyclonal antibody, researchers can investigate the expression and function of IL36RN in different cell types and tissues, providing insight into its role in inflammatory conditions. This antibody is a valuable tool for studies in dermatology, immunology, and inflammatory diseases, offering new opportunities for therapeutic development and disease management.
Product Name:
IL36RN Rabbit Polyclonal Antibody
SKU:
CAB8205
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-155 of human IL36RN (NP_036407.1).
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported.
Purification Method:
Affinity purification
Gene ID:
26525
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IL36RN antibody (CAB8205) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
