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GenieFluor 488 Anti-Human CD123 Antibody [6H6] (AGEL0445)

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SKU AGEL0445
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human
Host Species Mouse
Isotype IgG1
Clone 6H6
Conjugation AF 488
Applications FC
€113 - €495
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Description

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GenieFluor 488 Anti-Human CD123 Antibody [6H6]

The Human CD123 Monoclonal Antibody (ALEXA FLUOR 488 Conjugated) is a cutting-edge tool for researchers studying CD123, a cell surface marker associated with various immune cells, particularly in the context of leukemia and other hematological malignancies. This monoclonal antibody, clone 6H6 (AGEL0445), is conjugated with ALEXA FLUOR 488, a fluorescent dye known for its high sensitivity and brightness, allowing for precise visualization and detection of CD123 in experimental settings.CD123, also known as interleukin-3 receptor alpha chain, plays a crucial role in the development and function of myeloid cells, particularly dendritic cells and basophils. Its overexpression has been observed in certain leukemias, making it a potential target for therapeutic interventions.

By using this monoclonal antibody, researchers can accurately identify and analyze CD123-expressing cells in samples, aiding in the understanding of their role in disease pathogenesis and the development of targeted therapies.This antibody is specifically designed for use in flow cytometry and immunofluorescence applications, providing researchers with a powerful tool to elucidate the role of CD123 in both normal immune function and disease states. With its high specificity and sensitivity, the Human CD123 Monoclonal Antibody (ALEXA FLUOR 488 Conjugated) (6H6-AGEL0445) is a valuable resource for advancing research in immunology, oncology, and hematological disorders.

Product Title:GenieFluor 488 Anti-Human CD123 Antibody [6H6]
SKU:AGEL0445
Size:20 Tests, 100 Tests, 200 Tests
Clone No:6H6
Synonyms:IL-3Rα; IL-3 Receptor alpha;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor 488 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P26951
Gene ID:3563
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD123 is the 70 kD transmembrane α chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity; when CD123 associates with CDw131 (common β chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the β chain for this function. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells.

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