The IMMP2L Polyclonal Antibody (PACO09945) is a vital tool for researchers investigating IMMP2L, a protein involved in mitochondrial processing and localization. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the IMMP2L protein, this antibody enables precise detection and analysis in various cell types, making it ideal for studies in molecular biology and mitochondrial research.
IMMP2L plays a key role in mitochondrial function, particularly in the processing and localization of proteins within the organelle. Its importance in cellular metabolism and energy production makes it a promising target for research into mitochondrial diseases, neurodegenerative disorders, and metabolic syndromes. Investigating the functions of IMMP2L can provide insights into mitochondrial dysfunction and potential therapeutic interventions for related conditions.
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae);IMMP2L;IMP2;IMP2-LIKE ;
UniProt Protein Function:
IMMP2L: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. Defects in IMMP2L may be a cause of Gilles de la Tourette syndrome (GTS). GTS is a neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. Belongs to the peptidase S26 family. IMP2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.21.-; Mitochondrial; Membrane protein, integral; ProteaseChromosomal Location of Human Ortholog: 7q31Molecular Function: peptidase activity; serine-type endopeptidase activityBiological Process: mitochondrial protein processing; mitochondrial respiratory chain complex assembly; signal peptide processing
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011]
