The IPPK Polyclonal Antibody (PACO05058) is a valuable tool for research involving IPPK, an enzyme involved in the regulation of inositol phosphate metabolism. This antibody, produced in rabbits, shows high reactivity with human samples and is suitable for use in various applications, including Western blotting. By targeting the IPPK protein, this antibody allows for precise detection and analysis in different cell types, making it an ideal choice for studies in cell biology and metabolism research.IPPK plays a crucial role in cellular signaling pathways by converting IP5 to IP6, which impacts various cellular processes such as cell growth, metabolism, and gene expression.
Its involvement in inositol phosphate metabolism makes IPPK a potential target for investigating diseases related to dysregulation in these pathways, including cancer, diabetes, and neurological disorders. Understanding the function of IPPK is essential for developing targeted therapies aimed at correcting imbalances in inositol phosphate signaling.
IPPK: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. Belongs to the IPK1 type 2 family.Protein type: Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.158; Kinase, otherChromosomal Location of Human Ortholog: 9q22.31Cellular Component: nucleoplasm; intracellular; cytosolMolecular Function: inositol pentakisphosphate 2-kinase activity; ATP bindingBiological Process: inositol phosphate metabolic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010]
