The IPPK Polyclonal Antibody (PACO09984) is a valuable tool for researchers studying the inositol polyphosphate multikinase (IPMK) protein, which plays a crucial role in cellular signaling pathways regulating metabolism, growth, and survival. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications.IPPK, also known as IP5K, is involved in the synthesis of inositol pyrophosphates, important second messengers that regulate various cellular processes, including insulin signaling, energy metabolism, and cell proliferation. Dysregulation of IPPK has been linked to diseases such as cancer, diabetes, and neurodegenerative disorders, making it an attractive target for drug development and therapeutic interventions.
By facilitating the detection and analysis of IPPK in various cell types, the PACO09984 antibody enables researchers to deepen their understanding of the protein's function and its impact on cellular physiology. This antibody is an invaluable tool for studies in molecular biology, biochemistry, and pharmacology aimed at uncovering the intricate mechanisms underlying disease pathogenesis and identifying novel therapeutic targets.
IPPK: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. Belongs to the IPK1 type 2 family.Protein type: Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.158; Kinase, otherChromosomal Location of Human Ortholog: 9q22.31Cellular Component: nucleoplasm; intracellular; cytosolMolecular Function: inositol pentakisphosphate 2-kinase activity; ATP bindingBiological Process: inositol phosphate metabolic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010]
