The ISM2 Antibody (PAC020683) is a polyclonal antibody designed for research involving ISM2, a protein encoded by the ISM2 gene. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry. By binding to the ISM2 protein, this antibody allows for the detection and analysis of ISM2 in different cell types, making it a valuable tool for studies in molecular biology and genetics.ISM2 is a protein that plays a role in various cellular processes, including cell proliferation, differentiation, and apoptosis.
It is implicated in a range of diseases, including cancer, neurodegenerative disorders, and metabolic conditions. Research into the function and regulation of ISM2 is important for understanding its role in disease development and progression, as well as for identifying potential therapeutic targets for treatment.Overall, the ISM2 Antibody (PAC020683) is a reliable tool for investigating the function and regulation of ISM2 in various biological contexts, providing valuable insights into its potential as a target for therapeutic intervention in disease.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20683(ISM2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20683(ISM2 Antibody) at dilution 1/300 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20683(ISM2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene contains a type 1 thrombospondin domain, which is present in thrombospondin, a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.
Synonyms:
isthmin 2
UniProt Protein Function:
THSD3: contains a type 1 thrombospondin domain, which is present in thrombospondin, a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Mar 2009]Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 14q24.3
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a type 1 thrombospondin domain, which is present in thrombospondin, a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Mar 2009]
