The ITIH5 Polyclonal Antibody (PAC037238) is a valuable tool for researchers studying the ITIH5 protein, which is involved in various biological processes such as inflammation and immune response modulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications.ITIH5, a member of the inter-alpha-trypsin inhibitor (ITI) family, plays a crucial role in modulating inflammatory responses and maintaining tissue homeostasis. Dysregulation of ITIH5 has been implicated in diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
By targeting the ITIH5 protein with this antibody, researchers can gain insight into its function and potential therapeutic applications in these disease contexts.Overall, the ITIH5 Polyclonal Antibody (PAC037238) is a reliable tool for studying the biological roles of ITIH5 and its therapeutic implications in various disease conditions. Its high reactivity and validation for use in Western blotting make it a valuable asset for immunology and cancer research studies.
Antibody Name:
ITIH5 Antibody (PACO37238)
Antibody SKU:
PACO37238
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Inter-alpha-trypsin inhibitor heavy chain H5 protein (35-161AA)
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO37238 at dilution of 1:100.
Background:
May act as a tumor suppressor.
Synonyms:
Inter-alpha-trypsin inhibitor heavy chain H5 (ITI heavy chain H5) (ITI-HC5) (Inter-alpha-inhibitor heavy chain 5), ITIH5, KIAA1953
UniProt Protein Function:
ITIH5: May act as a tumor suppressor. Belongs to the ITIH family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 10p14
UniProt Protein Details:
NCBI Summary:
This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
