The IVL Polyclonal Antibody (CAB8026) is a valuable tool for researchers studying the IVL protein, which is involved in the formation of the epidermal cornified cell envelope. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the IVL protein, this antibody allows for the detection and analysis of IVL in a variety of cell types, making it ideal for studies in dermatology, skin biology, and wound healing research.
IVL, also known as involucrin, is a marker of terminal differentiation in keratinocytes and is crucial for the structural integrity of the skin barrier. Understanding the role of IVL in skin function and barrier formation is essential for developing therapies for conditions such as psoriasis, atopic dermatitis, and wound healing disorders. The IVL Polyclonal Antibody offers researchers a reliable tool to further explore the functions of IVL in these contexts and advance our understanding of skin biology.
Product Name:
IVL Rabbit Polyclonal Antibody
SKU:
CAB8026
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 416-585 of human IVL (NP_005538.2).
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
Purification Method:
Affinity purification
Gene ID:
3713
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IVL Rabbit pAb (CAB8026) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
