JNK2 Polyclonal Antibody
- SKU:
- CAB1251
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | JNK2 Polyclonal Antibody |
| Product Code: | CAB1251 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Positive Samples: | MCF-7, DU145, THP-1, Mouse liver |
| Cellular Location: | Cytoplasm, Nucleus |
| Customer Validation: | WB(Mouse heart tissue, Homo sapiens, Mus musculus, Danio rerio, Sus scrofa) |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-424 of human JNK2 (NP_002743.3). |
| Sequence: | MSDSK CDSQF YSVQV ADSTF TVLKR YQQLK PIGSG AQGIV CAAFD TVLGI NVAVK KLSRP FQNQT HAKRA YRELV LLKCV NHKNI ISLLN VFTPQ KTLEE FQDVY LVMEL MDANL CQVIH MELDH ERMSY LLYQM LCGIK HLHSA GIIHR DLKPS NIVVK SDCTL KILDF GLART ACTNF MMTPY VVTRY YRAPE VILGM GYKEN VDIWS VGCIM GELVK GCVIF QGTDH IDQWN KVIEQ LGTPS AEFMK KLQPT VRNYV ENRPK YPGIK FEELF PDWIF PSESE RDKIK TSQAR DLLSK MLVID PDKRI SVDEA LRHPY ITVWY DPAEA EAPPP QIYDA QLEER EHAIE EWKEL IYKEV MDWEE RSKNG VVKDQ PSDAA VSSNA TPSQS SSIND ISSMS TEQTL ASDTD SSLDA STGPL EGCR |
| Synonyms: | JNK2, SAPK, p54a, JNK2A, JNK2B, PRKM9, JNK-55, SAPK1a, JNK2BETA, p54aSAPK, JNK2ALPHA |
| Calculated MW: | 48kDa |
| Observed MW: | 54kDa |
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