The K-Cadherin (CDH6) Monoclonal Antibody (CAB4689) is a high-quality antibody developed for reliable detection and analysis of target proteins. This monoclonal antibody, generated in rabbits, exhibits strong reactivity with human samples and is validated for use in immunofluorescence and immunohistochemistry applications.K-Cadherin, also known as cadherin-6, plays a fundamental role in maintaining tissue integrity and architecture by mediating cell-cell adhesion. Dysregulation of K-Cadherin expression has been implicated in developmental disorders and various cancers, highlighting its importance in physiological and pathological conditions. The CAB4689 antibody enables precise detection and visualization of K-Cadherin expression, making it an invaluable tool for researchers investigating cell adhesion mechanisms, developmental biology, and cancer progression.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
K-Cadherin (CDH6) Monoclonal Antibody
SKU:
CAB4689
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC1093
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
CAD6, KCAD, K-Cadherin (CDH6)
Positive Sample:
293T, Hep G2, Mouse brain, Rat brain
Cellular Localization:
Cell Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:
88kDa
Observed MW:
130kDa
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis.
Purification Method
Affinity purification
Gene ID
1004
RRID
AB_2863323
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using K-Cadherin (CDH6) Rabbit mAb (CAB4689) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Western blot analysis of various lysates using K-Cadherin (CDH6) Rabbit mAb (CAB4689) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
