The KCNC2 Polyclonal Antibody (PAC023694) is a valuable tool for researchers studying the KCNC2 protein, which is involved in potassium channel activity in the brain. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the KCNC2 protein, researchers can easily detect and analyze its expression in various cell types, making it ideal for studies in neuroscience and neurology.KCNC2, also known as Kv3.2, plays a crucial role in regulating neuronal excitability and action potential firing in the brain. Dysregulation of KCNC2 has been implicated in neurological disorders such as epilepsy, ataxia, and schizophrenia, making it a promising target for therapeutic interventions.
Understanding the function of KCNC2 is essential for developing new treatments that target potassium channels and neuronal signaling pathways in these conditions.Overall, the KCNC2 Polyclonal Antibody is a valuable tool for researchers looking to explore the role of KCNC2 in brain function and neurological disorders. Its high specificity and sensitivity make it a reliable choice for studying potassium channel activity and neuronal excitability in various research settings.
Synthesized peptide derived from human Potassium Channel Kv3.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemical analysis of paraffin-embedded human brain tissue using Potassium Channel Kv3.2b antibody.
Western blot analysis of extracts from 293 cells (Lane 2), using Potassium Channel Kv3.2b antiobdy. The lane on the left is treated with synthesized peptide.
Western blot analysis of extracts from HepG2 cells, using Potassium Channel Kv3.2b antibody.
Background:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly By similarity.
Synonyms:
POTASSIUM CHANNEL; VOLTAGE-GATED; SHAW-RELATED SUBFAMILY; MEMBER 2;
UniProt Protein Function:
KCNC2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12q14.1
Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane
Biological Process: synaptic transmission; regulation of action potential; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerization
NCBI Summary:
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
