Description
KCND3 Antibody (CAB6927)
The KCND3 Antibody (CAB6927) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting KCND3 in human samples, making it an excellent choice for Western blot applications.By targeting the KCND3 protein, this antibody allows for the precise detection and analysis of potassium channel activity in various cell types, providing valuable insights into the role of KCND3 in cellular function and disease processes.
This antibody is validated for use in WB, IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
| Product Name: | KCND3 Antibody |
| SKU: | CAB6927 |
| Size: | 20μL, 100μL |
| Reactivity: | Human, Mouse, Rat |
| Conjugate: | Unconjugated |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. | ||||||
| Sequence: | MESS MQNY PSTR SPSL SSHP GLTT TCCS RRSK KTTH LPNS NLPA TRLR SMQE LSTI HIQG SEQP SLTT SRSS LNLK ADDG LRPN CKTS QITT AIIS IPTP PALT PEGE SRPP PASP GPNT NIPS IASN VVKV SAL | ||||||
| Tested Applications: | WB IHC-P ELISA | ||||||
| Recommended Dilution: |
| ||||||
| Synonyms: | KV4.3, SCA19, SCA22, BRGDA9, KCND3L, KCND3S, KSHIVB, KCND3 |
| Positive Sample: | A-549, SH-SY5Y, Mouse heart, Rat heart |
| Cellular Localization: | Cell Membrane, Cell Projection, Membrane, Multi-Pass Membrane Protein, Dendrite, Sarcolemma. |
| Calculated MW: | 73kDa |
| Observed MW: | 73kDa |
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.
| Purification Method | Affinity purification |
| Gene ID | 3752 |
| RRID | AB_2767486 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3. |
 | Western blot analysis of various lysates using KCND3 Rabbit pAb (CAB6927) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s. |
 | Immunohistochemistry analysis of paraffin-embedded Rat heart using KCND3 Rabbit pAb (CAB6927) at dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining. |
