The KCNG2 Antibody (PAC019880) is a valuable tool for researchers studying the KCNG2 protein, a voltage-gated potassium channel subunit involved in regulating neuronal excitability. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications.KCNG2 plays a crucial role in controlling the flow of potassium ions across cell membranes, which is essential for proper neuronal function. Dysregulation of KCNG2 has been implicated in various neurological disorders, including epilepsy and chronic pain conditions.
Therefore, studying the expression and activity of KCNG2 is important for understanding the underlying mechanisms of these diseases and developing targeted therapies.With its high reactivity and specificity, the KCNG2 Antibody is a valuable tool for investigating the function of KCNG2 in different cell types and tissues. Researchers in the fields of neuroscience, neurology, and pain research will find this antibody useful for their studies on neuronal excitability and potassium channel function.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19880(KCNG2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO19880(KCNG2 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19880(KCNG2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a γ subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization.
Synonyms:
potassium voltage-gated channel, subfamily G, member 2
UniProt Protein Function:
Kv6.2: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 18q23Cellular Component: plasma membraneMolecular Function: delayed rectifier potassium channel activityBiological Process: potassium ion transport; regulation of heart contraction; regulation of insulin secretion
UniProt Protein Details:
NCBI Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008]
