The KCNG3 Polyclonal Antibody (PAC019882) is a valuable tool for researchers studying the potassium voltage-gated channel subfamily G member 3 (KCNG3) protein. This antibody, derived from rabbit serum, exhibits high specificity and reactivity with human samples, making it ideal for use in Western blotting and immunofluorescence applications. By binding to the KCNG3 protein, this antibody allows for precise detection and analysis in a variety of cell types, facilitating investigations in neuroscience and cardiovascular research.KCNG3 is a crucial component of voltage-gated potassium channels, playing a key role in regulating electrical signaling in neurons and cardiac cells.
Dysregulation of KCNG3 has been associated with various neurological and cardiovascular disorders, making it an important target for therapeutic interventions. Research into the function and expression of KCNG3 is essential for developing treatments for conditions such as epilepsy, arrhythmias, and other channelopathies.Overall, the KCNG3 Polyclonal Antibody provides researchers with a reliable tool for studying the role of KCNG3 in physiological and pathological processes, ultimately contributing to the advancement of knowledge and potential therapies in the fields of neuroscience and cardiology.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19882(KCNG3 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: PACO19882(KCNG3 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19882(KCNG3 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a γ subunit functioning as a modulatory molecule.
Synonyms:
potassium voltage-gated channel, subfamily G, member 3
UniProt Protein Function:
KCNG3: Potassium channel subunit. Modulates channel activity. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 2p21Cellular Component: endoplasmic reticulum; plasma membrane; voltage-gated potassium channel complexMolecular Function: delayed rectifier potassium channel activity; protein binding
UniProt Protein Details:
NCBI Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
