The KCNG3 Polyclonal Antibody (PAC019883) is specifically designed for research involving the KCNG3 protein, a voltage-gated potassium channel subunit. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the KCNG3 protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal tool for studies in neuroscience and cardiovascular research.KCNG3 is a key player in regulating cellular excitability and action potential repolarization in neurons and cardiac myocytes.
Its role in ion channel function makes it a target of interest in understanding neurological disorders and cardiac arrhythmias. Research on KCNG3 can provide valuable insights into the mechanisms underlying these conditions, potentially leading to the development of novel therapeutic interventions.By utilizing the KCNG3 Polyclonal Antibody, researchers can effectively study the expression and function of KCNG3 in different experimental settings, ultimately advancing our understanding of the physiological and pathological roles of this important potassium channel subunit.
Antibody Name:
KCNG3 Antibody (PACO19883)
Antibody SKU:
PACO19883
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human KCNG3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19883(KCNG3 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19883(KCNG3 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a γ subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms.
Synonyms:
potassium voltage-gated channel, subfamily G, member 3
UniProt Protein Function:
KCNG3: Potassium channel subunit. Modulates channel activity. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 2p21Cellular Component: endoplasmic reticulum; plasma membrane; voltage-gated potassium channel complexMolecular Function: delayed rectifier potassium channel activity; protein binding
UniProt Protein Details:
NCBI Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
